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        Nc2Eye

           A curated ncRNAomics knowledgebase for bridging basic and clinical research in eye diseases.

Detail of uveal melanoma (UM)
ncRNA name hsa-miR-27a
ncRNA Category miRNA
Disease name uveal melanoma (UM)
Species Homo sapiens
Tissues/Cell_line human UM cell line C918
Methods MTT assay, qRT-PCR
Expression pattern associated
Functional description We for the first time report a correlation between antitumor activity of genistein and miR-27a mediated regulatory mechanism. Genistein markedly inhibited miR-27a expression.The levels of miR-27a and its target gene ZBTB10 were significantly different based on the dose of genistein.
PubMed ID 19639204
Year 2009
Title Genistein inhibits growth of human uveal melanoma cells and affects microRNA-27a and target gene expression.
Drug-related ncRNA YES (Genistein)

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